Synthetic Peptide for Melanocortin Receptor Research

Technical Overview

PT-141 (bremelanotide) is a cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH) featuring a side-chain lactam bridge between Asp and Lys, N-terminal acetylation, and incorporation of norleucine and D-phenylalanine for protease resistance. It is a non-selective agonist of MC1R, MC3R, MC4R, and MC5R with preferential activity at MC3R/MC4R.

Researchers use PT-141 to investigate central melanocortin signaling, sexual-behavior circuits in rodent models, and receptor-selectivity comparisons against alpha-MSH and NDP-MSH. Its protease-resistant structure makes it a stable reference compound for melanocortin receptor pharmacology.

This compound is synthesized using established solid-phase peptide synthesis methods and purified through reversed-phase HPLC to achieve analytical purity suitable for laboratory assays, binding studies, and analytical applications. The lyophilized material is supplied for reconstitution per established laboratory protocols and is intended as a reference material in controlled research environments.

Specifications

Compound Name: PT-141
Strength: 10mg
Purity: ≥ 99% (HPLC Verified)
Appearance: Lyophilized Peptide Powder
Format: Research Compound
Reconstitution: Suitable for laboratory assay preparation.

Notice

Provided as a reference material for scientific investigation only.