Synthetic Peptide for Growth Factor Research

Technical Overview

IGF-1 LR3 is a recombinant 83-residue IGF-1 analog with arginine substituted for glutamic acid at position 3 and an additional 13-residue N-terminal extension. These modifications dramatically reduce binding to IGF binding proteins (IGFBP-1 through IGFBP-6), increasing the proportion of bioavailable peptide for receptor interaction in cell-culture systems.

Researchers utilize this analog to study cell-cycle progression, protein synthesis, and survival signaling in myoblast, hepatocyte, and stem-cell models. Its reduced IGFBP affinity makes it a preferred tool for distinguishing receptor-mediated effects from binding-protein-mediated sequestration.

This compound is synthesized using established solid-phase peptide synthesis methods and purified through reversed-phase HPLC to achieve analytical purity suitable for laboratory assays, binding studies, and analytical applications. The lyophilized material is supplied for reconstitution per established laboratory protocols and is intended as a reference material in controlled research environments.

Specifications

Compound Name: IGF-1 LR3
Strength: 1mg
Purity: ≥ 99% (HPLC Verified)
Appearance: Lyophilized Peptide Powder
Format: Research Compound
Reconstitution: Suitable for laboratory assay preparation.

Notice

Provided as a reference material for scientific investigation only.